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Its strongest genetic-study result is p = 10−8, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 354,862 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0229 lower (95% confidence interval 0.015-0.031); p = 4 × 10−9.
How common The A allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 15, band 15q26.2 — between genes, 124.7 kb from FAM149B1P1.
What each result means
A/ATwo copies of the version the research linked to Depressive symptoms (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Depressive symptoms (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Depressive symptoms (MTAG). This is the starting point the study compared everyone against.
Nature genetics · 2018 · PMID 29292387 · open access
Questions about rs9944275
What is rs9944275?
rs9944275 is a single position in the genome, in or near the near FAM149B1P1 gene. Published research associates it with depressive symptoms (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9944275 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs9944275 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9944275 come from?
GWAS Catalog, Nature genetics 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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