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High density lipoprotein cholesterol levels

CETP · rs9923854

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Drug: Statins

rs9923854 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Drug: Statins Statins Drug rs9923854 rs9923854 CETP

What the study found

Who was studied 76,627 European ancestry individuals, 7,795 Hispanic individuals, 6,855 East Asian ancestry individuals, 2,958 African American individuals, 439 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.082 lower (95% confidence interval -); p = 1 × 10−41.

Where it sits Chromosome 16, band 16q13 — in an intron of CETP.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-09-22. ClinVar record 1222632 NM_000078.3(CETP):c.1322-236T>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9923854

What is rs9923854?

rs9923854 is a single position in the genome, in or near the CETP gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9923854 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does rs9923854 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9923854 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9923854 come from?

GWAS Catalog, Nat Genet 2018, PMID:29507422. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High density lipoprotein cholesterol levels (rs9923854). MyGeneLog™. https://www.mygenelog.com/variants/rs9923854

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