Who was studied 57,290 European ancestry cases, 324,430 European ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0491 higher (95% confidence interval 0.034-0.064); p = 3 × 10−10.
How common The G allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 3, band 3q23 — in an intron of ZBTB38.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Age-related macular degeneration — no copies of the reported risk allele.
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Age-related macular degeneration.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Age-related macular degeneration compared to the general population.
rs9821337 is a single position in the genome, in or near the ZBTB38 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs9821337 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs9821337 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9821337 come from?
GWAS Catalog, Nature genetics 2024, PMID:39623103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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