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Monocyte count

PLCB1 · rs978266

Where this position leads

Condition: Monocyte Count

rs978266 Condition: Monocyte Count Monocyte Count Condition rs978266 rs978266 PLCB1

What the study found

Who was studied 408,112 British individuals.

The effect Each copy of the G allele shifted the measure 0.0142 lower (95% confidence interval 0.0098-0.0186); p = 2 × 10−10.

How common The G allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 20, band 20p12.3 — in an intron of PLCB1.

What each result means

A/A No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs978266

What is rs978266?

rs978266 is a single position in the genome, in or near the PLCB1 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs978266 linked to?

On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.

Does having rs978266 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs978266 come from?

GWAS Catalog, Cell 2020, PMID:32888494. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Monocyte count (rs978266). MyGeneLog™. https://www.mygenelog.com/variants/rs978266

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