near APOB · rs952275
Where this position leads
Condition: Age-Related Macular Degeneration
Strength of the evidence
Its strongest genetic-study result is p = 10−114, with 36 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 98,316 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0544 higher (95% confidence interval 0.049-0.06); p = 7 × 10−84.
How common The T allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 2, band 2p24.1 — between genes, 2.9 kb from APOB.
How common each version is
GT
G 5.4% · T 94.6%
G 5.2% · T 94.8%
G 3.7% · T 96.3%
G 37.9% · T 62.1%
G 25.3% · T 74.7%
G 37.4% · T 62.6%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs952275 is a single position in the genome, in or near the near APOB gene. Published research associates it with phospholipids to total lipids in small hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Phospholipids to Total Lipids in Small HDL percentage (rs952275). MyGeneLog™. https://www.mygenelog.com/variants/rs952275