Standard

Monocyte count

near LINC00399 · rs9521344

Where this position leads

Conditions: Blood Cell Counts, Monocyte Count, Colon Polyp

rs9521344 Condition: Blood Cell Counts Blood Cell Counts Condition Condition: Monocyte Count Monocyte Count Condition Condition: Colon Polyp Colon Polyp Condition rs9521344 rs9521344 near LINC003…

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−27, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 349,856 European ancestry individuals, 95,119 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0232 lower (95% confidence interval 0.019-0.027); p = 9 × 10−28.

Where it sits Chromosome 13, band 13q33.3 — between genes, 16.1 kb from LINC00399.

What each result means

C/C No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs9521344

What is rs9521344?

rs9521344 is a single position in the genome, in or near the near LINC00399 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9521344 linked to?

On MyGeneLog this position is linked to Blood Cell Counts, Monocyte Count, Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs9521344 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9521344 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Monocyte count (rs9521344). MyGeneLog™. https://www.mygenelog.com/variants/rs9521344

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