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Feeling guilty

SLC17A4 · rs9461218

Where this position leads

Condition: Irritable Mood

rs9461218 Condition: Irritable Mood Irritable Mood Condition rs9461218 rs9461218 SLC17A4

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling guilty compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling guilty.
G/G Published research associates this genotype with typical/baseline likelihood of Feeling guilty — no copies of the reported risk allele.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs9461218

What is rs9461218?

rs9461218 is a single position in the genome, in or near the SLC17A4 gene. Published research associates it with feeling guilty. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9461218 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does having rs9461218 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9461218 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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