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Age-related macular degeneration

CFB · rs9380272

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Age-related macular degeneration compared to the general population. (GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Age-related macular degeneration. (GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819)

G/G Published research associates this genotype with typical/baseline likelihood of Age-related macular degeneration — no copies of the reported risk allele. (GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819)

Source: GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819

Questions about rs9380272

What is rs9380272?

rs9380272 is a single position in the genome, in or near the CFB gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9380272 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9380272 come from?

GWAS Catalog, Proc Natl Acad Sci U S A 2010, PMID:20385819. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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