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DNA methylation Hannum age acceleration

F5 · rs9332539

Where this position leads

What the study found

Who was studied 6,148 African American individuals.

The effect Each copy of the T allele shifted the measure 1.21 lower (95% confidence interval 0.94-1.47); p = 2 × 10⁻¹⁹.

How common The T allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — in an intron of F5.

What each result means

A/A No copy of the version the research linked to DNA methylation Hannum age acceleration. This is the starting point the study compared everyone against.

A/T One copy of the version the research linked to DNA methylation Hannum age acceleration. That is a smaller link than two copies.

T/T Two copies of the version the research linked to DNA methylation Hannum age acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, Broer L, Guo X, Jeong A, Jung J, Kasela S, Katrinli S

and 97 more — show all

Kuo PL, Matias-Garcia PR, Mishra PP, Nygaard M, Palviainen T, Patki A, Raffield LM, Ratliff SM, Richardson TG, Robinson O, Soerensen M, Sun D, Tsai PC, van der Zee MD, Walker RM, Wang X, Wang Y, Xia R, Xu Z, Yao J, Zhao W, Correa A, Boerwinkle E, Dugué PA, Durda P, Elliott HR, Gieger C, de Geus EJC, Harris SE, Hemani G, Imboden M, Kähönen M, Kardia SLR, Kresovich JK, Li S, Lunetta KL, Mangino M, Mason D, McIntosh AM, Mengel-From J, Moore AZ, Murabito JM, Ollikainen M, Pankow JS, Pedersen NL, Peters A, Polidoro S, Porteous DJ, Raitakari O, Rich SS, Sandler DP, Sillanpää E, Smith AK, Southey MC, Strauch K, Tiwari H, Tanaka T, Tillin T, Uitterlinden AG, Van Den Berg DJ, van Dongen J, Wilson JG, Wright J, Yet I, Arnett D, Bandinelli S, Bell JT, Binder AM, Boomsma DI, Chen W, Christensen K, Conneely KN, Elliott P, Ferrucci L, Fornage M, Hägg S, Hayward C, Irvin M, Kaprio J, Lawlor DA, Lehtimäki T, Lohoff FW, Milani L, Milne RL, Probst-Hensch N, Reiner AP, Ritz B, Rotter JI, Smith JA, Taylor JA, van Meurs JBJ, Vineis P, Waldenberger M, Deary IJ, Relton CL, Horvath S, Marioni RE

Genetics of DNA Methylation Consortium · NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Genome biology · 2021 · PMID 34187551 · open access

Questions about rs9332539

What is rs9332539?

rs9332539 is a single position in the genome, in or near the F5 gene. Published research associates it with dna methylation hannum age acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs9332539 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9332539 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9332539 come from?

GWAS Catalog, Genome biology 2021, PMID:34187551. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

DNA methylation Hannum age acceleration (rs9332539). MyGeneLog™. https://www.mygenelog.com/variants/rs9332539

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