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Seborrheic keratosis (PheCode 702.2)

near TP63 · rs9290890

Where this position leads

Condition: Seborrheic Keratosis

rs9290890 Condition: Seborrheic Keratosis Seborrheic Keratosis Condition rs9290890 rs9290890 near TP63

What the study found

Who was studied 3,192 African American or Afro-Caribbean cases, 112,982 African American or Afro-Caribbean controls, 4,518 Hispanic or Latin American cases, 50,328 Hispanic or Latin American controls, 356 East Asian ancestry cases, 6,050 East Asian ancestry controls, 88,990 European ancestry cases, 303,479 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0867 higher (95% confidence interval 0.074-0.1); p = 2 × 10−45.

How common The A allele had a frequency of about 52% in the people studied.

Where it sits Chromosome 3, band 3q28 — between genes, 152.6 kb from TP63.

What each result means

A/A Two copies of the version the research linked to Seborrheic keratosis (PheCode 702.2). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Seborrheic keratosis (PheCode 702.2). That is a smaller link than two copies.
C/C No copy of the version the research linked to Seborrheic keratosis (PheCode 702.2). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs9290890

What is rs9290890?

rs9290890 is a single position in the genome, in or near the near TP63 gene. Published research associates it with seborrheic keratosis (phecode 702.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9290890 linked to?

On MyGeneLog this position is linked to Seborrheic Keratosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9290890 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9290890 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Seborrheic keratosis (PheCode 702.2) (rs9290890). MyGeneLog™. https://www.mygenelog.com/variants/rs9290890

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