Seborrheic Keratosis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 97,056 cases and 472,839 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Seborrheic Keratosis (the GWAS Catalog's "Seborrheic keratosis (PheCode 702.2)"): 5 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 97,056 cases and 472,839 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). The 5 positions on this page from it: rs9290890 (near TP63), rs11217816 (near POU2F3), rs2036204 (ANKRD50), rs1539690 (near PKP1), rs12117155 (TUFT1). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: TP63, POU2F3, ANKRD50, PKP1, TUFT1. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
The strongest association in the records is rs9290890 near TP63, reported by Verma A et al. 2024 at P = 2 × 10-45.
Read this page as a list of findings about Seborrheic Keratosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
A genotype does not diagnose Seborrheic Keratosis; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Seborrheic Keratosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Seborrheic Keratosis. MyGeneLog™. https://www.mygenelog.com/conditions/seborrheic-keratosis
Seborrheic Keratosis is the condition the GWAS Catalog files under "Seborrheic keratosis (PheCode 702.2)". This page does not define it in its own words; it lists what genome-wide studies have reported: 5 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 97,056 cases and 472,839 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: TP63, POU2F3, ANKRD50, PKP1, TUFT1. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Seborrheic Keratosis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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