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Uncharacterized protein KIAA0040 levels

F5 · rs9287092

Where this position leads

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.139 higher (95% confidence interval 0.11-0.17); p = 6 × 10⁻²¹.

How common The A allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — in an intron of F5.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-11-11. ClinVar record 1268054 NM_000130.5(F5):c.1975+98G>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Uncharacterized protein KIAA0040 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/C One copy of the version the research linked to Uncharacterized protein KIAA0040 levels. That is a smaller link than two copies.

C/C No copy of the version the research linked to Uncharacterized protein KIAA0040 levels. This is the starting point the study compared everyone against.

Source

Mapping the proteo-genomic convergence of human diseases

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J

and 9 more — show all

Arnold M, Arlt W, O'Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C

Science (New York, N.Y.) · 2021 · PMID 34648354

Questions about rs9287092

What is rs9287092?

rs9287092 is a single position in the genome, in or near the F5 gene. Published research associates it with uncharacterized protein kiaa0040 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs9287092 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9287092 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9287092 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Uncharacterized protein KIAA0040 levels (rs9287092). MyGeneLog™. https://www.mygenelog.com/variants/rs9287092

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