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Sialic acid-binding Ig-like lectin 11 levels (SIGLEC11.8913.22.3)

F5 · rs9287090

Where this position leads

Drug: Combined hormonal contraceptives

rs9287090 Drug: Combined hormonal contraceptives Combined hormonal contraceptives Drug rs9287090 rs9287090 F5

What the study found

Who was studied 3,301 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.55 higher (95% confidence interval 0.49-0.61); p = 9 × 10−97.

How common The A allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 1, band 1q24.2 — a synonymous change in F5.

What ClinVar records

Classification Benign/Likely benign for Factor V deficiency, Budd-Chiari syndrome, Congenital factor V deficiency, Thrombophilia due to thrombin defect; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 8 submitters), last evaluated 2026-02-04. ClinVar record 255206 NM_000130.5(F5):c.3948C>T (p.Leu1316=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Sialic acid-binding Ig-like lectin 11 levels (SIGLEC11.8913.22.3). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Sialic acid-binding Ig-like lectin 11 levels (SIGLEC11.8913.22.3). That is a smaller link than two copies.
G/G No copy of the version the research linked to Sialic acid-binding Ig-like lectin 11 levels (SIGLEC11.8913.22.3). This is the starting point the study compared everyone against.
Source
Genomic atlas of the human plasma proteome
Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat MA
and 21 more — show all
Prins BP, Wilcox SK, Zimmerman ES, Chi A, Bansal N, Spain SL, Wood AM, Morrell NW, Bradley JR, Janjic N, Roberts DJ, Ouwehand WH, Todd JA, Soranzo N, Suhre K, Paul DS, Fox CS, Plenge RM, Danesh J, Runz H, Butterworth AS
Nature · 2018 · PMID 29875488

Questions about rs9287090

What is rs9287090?

rs9287090 is a single position in the genome, in or near the F5 gene. Published research associates it with sialic acid-binding ig-like lectin 11 levels (siglec11.8913.22.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs9287090 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9287090 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9287090 come from?

GWAS Catalog, Nature 2018, PMID:29875488. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Sialic acid-binding Ig-like lectin 11 levels (SIGLEC11.8913.22.3) (rs9287090). MyGeneLog™. https://www.mygenelog.com/variants/rs9287090

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