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Plantar warts

HLA-DRB1 · rs9272050

Where this position leads

Condition: Tonsillectomy (Throat Infection Susceptibility)

rs9272050 Condition: Tonsillectomy (Throat Infection Susceptibility) Tonsillectomy (Throat Infection Sus… Condition rs9272050 rs9272050 HLA-DRB1

What the study found

Who was studied 24,994 European ancestry cases, 37,451 European ancestry controls.

The effect Each copy of the G allele shifted the measure 1.19 higher (95% confidence interval 1.17-1.21); p = 1 × 10−30.

How common The G allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — inside HLA-DQA1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Plantar warts — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Plantar warts.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Plantar warts compared to the general population.
Source
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nature communications · 2017 · PMID 28928442 · open access

Questions about rs9272050

What is rs9272050?

rs9272050 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with plantar warts. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9272050 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility). The research behind each link, and its sources, are set out on that condition page.

Does having rs9272050 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9272050 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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