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Body shape phenotype PC2

HLA-DRB1 · rs9270074

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻⁴¹, with 6 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 460,198 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0401 higher (95% confidence interval 0.034-0.046); p = 2 × 10⁻⁴¹.

How common The T allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DRB1.

How common each version is

CT

Korean KRGDB

C 35.3% · T 64.7%

World gnomAD

C 0.1% · T 99.9%

World 1000 Genomes

C 37.9% · T 62.1%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Body shape phenotype PC2. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Body shape phenotype PC2. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Body shape phenotype PC2. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer

Peruchet-Noray L, Sedlmeier AM, Dimou N, Baurecht H, Fervers B, Fontvieille E, Konzok J, Tsilidis KK, Christakoudi S, Jansana A, Cordova R, Bohmann P

and 18 more — show all

Stein MJ, Weber A, Bézieau S, Brenner H, Chan AT, Cheng I, Figueiredo JC, Garcia-Etxebarria K, Moreno V, Newton CC, Schmit SL, Song M, Ulrich CM, Ferrari P, Viallon V, Carreras-Torres R, Gunter MJ, Freisling H

Science advances · 2024 · PMID 38640244 · open access

Questions about rs9270074

What is rs9270074?

rs9270074 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with body shape phenotype pc2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs9270074 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9270074 come from?

GWAS Catalog, Science advances 2024, PMID:38640244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body shape phenotype PC2 (rs9270074). MyGeneLog™. https://www.mygenelog.com/variants/rs9270074

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