Sensitive

Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive)

HLA-DRB1 · rs9269234

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁵, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 357 African admixed and non-African admixed Arab ancestry cases, 352 African admixed and non-African admixed Arab ancestry controls; replicated in 234 Arab ancestry cases, 225 Arab ancestry controls.

The effect Each copy of the G allele carried 2.14 times the odds of Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) (95% confidence interval 1.78-2.57); p = 6 × 10⁻¹⁶.

How common The G allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 10.5 kb from HLA-DRB9.

How common each version is

CG

Korean KRGDB

C 32.5% · G 67.5%

Korean Korea4K

C 31.9% · G 68.1%

Korean Korea1K

C 21.1% · G 78.9%

Japanese ToMMo

C 30.3% · G 69.7%

World gnomAD

C 32.7% · G 67.3%

World 1000 Genomes

C 31.8% · G 68.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive). This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A Multinational Arab Genome-Wide Association Study Identifies New Genetic Associations for Rheumatoid Arthritis

Saxena R, Plenge RM, Bjonnes AC, Dashti HS, Okada Y, Gad El Haq W, Hammoudeh M, Al Emadi S, Masri BK, Halabi H, Badsha H, Uthman IW

and 8 more — show all

Margolin L, Gupta N, Mahfoud ZR, Kapiri M, Dargham SR, Aranki G, Kazkaz LA, Arayssi T

Arthritis & rheumatology (Hoboken, N.J.) · 2017 · PMID 28118524

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) (rs9269234). MyGeneLog™. https://www.mygenelog.com/variants/rs9269234

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