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Idiopathic pulmonary fibrosis

near ZDHHC20P2 · rs9266669

Where this position leads

Condition: Idiopathic Pulmonary Fibrosis

What the study found

Who was studied 169 African ancestry cases, 8,368 African ancestry controls, 319 Admixed American ancestry cases, 14,452 Admixed American ancestry controls, 51 South Asian ancestry cases, 21,897 South Asian ancestry controls, 1,210 East Asian ancestry cases, 254,409 East Asian ancestry controls, 6,257 European ancestry cases, 947,616 European ancestry controls; replicated in 193 African ancestry cases, 8,862 African ancestry controls, 642 European ancestry cases, 24,665 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.144 higher (95% confidence interval 0.096-0.192); p = 4 × 10⁻⁹.

How common The A allele had a frequency of about 14% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.1 kb from ZDHHC20P2.

What each result means

A/A Two copies of the version the research linked to Idiopathic pulmonary fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Idiopathic pulmonary fibrosis. That is a smaller link than two copies.

G/G No copy of the version the research linked to Idiopathic pulmonary fibrosis. This is the starting point the study compared everyone against.

Source

Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN

and 140 more — show all

Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M, Ding Y, Feng YA, Guare LA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Ismail SI, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Moreno-Grau S, Nam K, Palta P, Pandit A, Preuss MH, Saad C, Setia-Verma S, Thorsteinsdottir U, Uzunovic J, Verma A, Zawistowski M, Zhong X, Afifi N, Al-Dabhani KM, Al Thani A, Bradford Y, Campbell A, Crooks K, de Bock GH, Damrauer SM, Douville NJ, Finer S, Fritsche LG, Fthenou E, Gonzalez-Arroyo G, Griffiths CJ, Guo Y, Hunt KA, Ioannidis A, Jansonius NM, Konuma T, Lee MTM, Lopez-Pineda A, Matsuda Y, Marioni RE, Moatamed B, Nava-Aguilar MA, Numakura K, Patil S, Rafaels N, Richmond A, Rojas-Muñoz A, Shortt JA, Straub P, Tao R, Vanderwerff B, Vernekar M, Veturi Y, Barnes KC, Boezen M, Chen Z, Chen CY, Cho J, Smith GD, Finucane HK, Franke L, Gamazon ER, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Katsanis N, Koskela JT, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM, Porteous DJ, Shavit JA, Snieder H, Takano T, Trembath RC, Vonk JM, Whiteman DC, Wicks SJ, Wijmenga C, Wright J, Zheng J, Zhou X, Awadalla P, Boehnke M, Bustamante CD, Cox NJ, Fatumo S, Geschwind DH, Hayward C, Hveem K, Kenny EE, Lee S, Lin YF, Mbarek H, Mägi R, Martin HC, Medland SE, Okada Y, Palotie AV, Pasaniuc B, Rader DJ, Ritchie MD, Sanna S, Smoller JW, Stefansson K, van Heel DA, Walters RG, Zöllner S, Martin AR, Willer CJ, Daly MJ, Neale BM

Cell genomics · 2022 · PMID 36777996 · open access

Questions about rs9266669

What is rs9266669?

rs9266669 is a single position in the genome, in or near the near ZDHHC20P2 gene. Published research associates it with idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9266669 linked to?

On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9266669 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9266669 come from?

GWAS Catalog, Cell genomics 2022, PMID:36777996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Idiopathic pulmonary fibrosis (rs9266669). MyGeneLog™. https://www.mygenelog.com/variants/rs9266669

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