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Free Cholesterol to Total Lipids in Very Large HDL percentage

near HLA-B · rs9265965

Where this position leads

Condition: Age-Related Macular Degeneration

rs9265965 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs9265965 rs9265965 near HLA-B

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0751 higher (95% confidence interval 0.048-0.102); p = 2 × 10−8.

How common The C allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 6 kb from HLA-B.

What each result means

C/C Two copies of the version the research linked to Free Cholesterol to Total Lipids in Very Large HDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Free Cholesterol to Total Lipids in Very Large HDL percentage. That is a smaller link than two copies.
T/T No copy of the version the research linked to Free Cholesterol to Total Lipids in Very Large HDL percentage. This is the starting point the study compared everyone against.
Source

Questions about rs9265965

What is rs9265965?

rs9265965 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with free cholesterol to total lipids in very large hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9265965 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs9265965 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9265965 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Free Cholesterol to Total Lipids in Very Large HDL percentage (rs9265965). MyGeneLog™. https://www.mygenelog.com/variants/rs9265965

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