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Sensitive

Systemic sclerosis

SLC12A5 · rs9074

Where this position leads

Condition: Systemic Sclerosis

rs9074 Condition: Systemic Sclerosis Systemic Sclerosis Condition rs9074 rs9074 SLC12A5

What the study found

Who was studied 9,095 European ancestry cases, 17,584 European ancestry controls, 1,428 Japanese ancestry cases, 112,599 Japanese ancestry controls.

The effect Each copy of the A allele shifted the measure 0.05 higher (95% confidence interval 0.0088-0.0912); p = 2 × 10−8.

Where it sits Chromosome 20, band 20q13.12 — in the 3′ untranslated region of SLC12A5.

What each result means

A/A Two copies of the version the research linked to Systemic sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Systemic sclerosis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Systemic sclerosis. This is the starting point the study compared everyone against.
Source
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Ishikawa Y, Tanaka N, Asano Y, Kodera M, Shirai Y, Akahoshi M, Hasegawa M, Matsushita T, Saito K, Motegi SI, Yoshifuji H, Yoshizaki A
and 60 more — show all
Kohmoto T, Takagi K, Oka A, Kanda M, Tanaka Y, Ito Y, Nakano K, Kasamatsu H, Utsunomiya A, Sekiguchi A, Niiro H, Jinnin M, Makino K, Makino T, Ihn H, Yamamoto M, Suzuki C, Takahashi H, Nishida E, Morita A, Yamamoto T, Fujimoto M, Kondo Y, Goto D, Sumida T, Ayuzawa N, Yanagida H, Horita T, Atsumi T, Endo H, Shima Y, Kumanogoh A, Hirata J, Otomo N, Suetsugu H, Koike Y, Tomizuka K, Yoshino S, Liu X, Ito S, Hikino K, Suzuki A, Momozawa Y, Ikegawa S, Tanaka Y, Ishikawa O, Takehara K, Torii T, Sato S, Okada Y, Mimori T, Matsuda F, Matsuda K, Amariuta T, Imoto I, Matsuo K, Kuwana M, Kawaguchi Y, Ohmura K, Terao C
Nature communications · 2024 · PMID 38296975 · open access

Questions about rs9074

What is rs9074?

rs9074 is a single position in the genome, in or near the SLC12A5 gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9074 linked to?

On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs9074 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9074 come from?

GWAS Catalog, Nature communications 2024, PMID:38296975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic sclerosis (rs9074). MyGeneLog™. https://www.mygenelog.com/variants/rs9074

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