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Cancer of other male genital organs (PheCode 187)

NWD2 · rs905839831

Where this position leads

Condition: Cancer of Other Male Genital Organs

rs905839831 Condition: Cancer of Other Male Genital Organs Cancer of Other Male Genital Organs Condition rs905839831 rs905839831 NWD2

What the study found

Who was studied 453 African American or Afro-Caribbean cases, 103,757 African American or Afro-Caribbean controls, 2,251 European ancestry cases, 412,592 European ancestry controls, 314 Hispanic or Latin American cases, 53,258 Hispanic or Latin American controls.

The effect Each copy of the T allele shifted the measure 3.61 lower (95% confidence interval 3.6-3.63); p = 2 × 10−12.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 4, band 4p14 — in an intron of NWD2.

What each result means

C/C No copy of the version the research linked to Cancer of other male genital organs (PheCode 187). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cancer of other male genital organs (PheCode 187). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cancer of other male genital organs (PheCode 187). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs905839831

What is rs905839831?

rs905839831 is a single position in the genome, in or near the NWD2 gene. Published research associates it with cancer of other male genital organs (phecode 187). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs905839831 linked to?

On MyGeneLog this position is linked to Cancer of Other Male Genital Organs. The research behind each link, and its sources, are set out on that condition page.

Does having rs905839831 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs905839831 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cancer of other male genital organs (PheCode 187) (rs905839831). MyGeneLog™. https://www.mygenelog.com/variants/rs905839831

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