AP3S2 · rs893617
Where this position leads
Condition: Type 2 Diabetes
What the study found
Who was studied 148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls.
The effect Each copy of the C allele shifted the measure 0.0537 higher (95% confidence interval 0.046-0.062); p = 2 × 10−38.
How common The C allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 15, band 15q26.1 — in an intron of AP3S2.
rs893617 is a single position in the genome, in or near the AP3S2 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs893617). MyGeneLog™. https://www.mygenelog.com/variants/rs893617