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Phospholipids in very large HDL

near JAZF1 · rs849336

Where this position leads

Condition: Age-Related Macular Degeneration

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.00227 lower (95% confidence interval 0.0016-0.0029); p = 4 × 10⁻¹².

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 7, band 7p15.1 — in an intron of JAZF1-AS1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Phospholipids in very large HDL compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Phospholipids in very large HDL.

G/G Published research associates this genotype with typical/baseline likelihood of Phospholipids in very large HDL — no copies of the reported risk allele.

Source

Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration

Farashi S, Bonelli R, Jackson VE, Ansell BRE, Guymer RH, Bahlo M

Ophthalmology science · 2024 · PMID 39091897 · open access

Questions about rs849336

What is rs849336?

rs849336 is a single position in the genome, in or near the near JAZF1 gene. Published research associates it with phospholipids in very large hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs849336 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs849336 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs849336 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Phospholipids in very large HDL (rs849336). MyGeneLog™. https://www.mygenelog.com/variants/rs849336

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