Sensitive

Type 2 diabetes

JAZF1 · rs849134

Where this position leads

What the study found

Who was studied 8,130 European ancestry cases, 38,987 European ancestry controls; replicated in Up to 34,412 European ancestry cases, 59,925 European ancestry controls.

The effect Each copy of the A allele carried 1.13 times the odds of Type 2 diabetes (95% confidence interval 1.09-1.18); p = 3 × 10⁻⁹.

Where it sits Chromosome 7, band 7p15.1 — in an intron of JAZF1.

What each result means

A/A Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

Source

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T

and 146 more — show all

Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI

MAGIC investigators · GIANT Consortium

Nature genetics · 2010 · PMID 20581827

What people read about alongside this

Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

In the news

2026-06-01 · Brito Nunes C, et al., Nature Communications 2026, PMID:42225636

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

Gestational diabetes affects about 14% of pregnancies and raises the mother's later risk of type 2 diabetes. The GenDiP Consortium's meta-analysis covers up to 38,305 women with gestational diabetes and 776,145 controls and finds 37 associated loci, 7 of them new, plus five new loci for blood sugar traits in pregnancy — all acting through the mother's genome rather than the baby's. Every locus overlaps type 2 diabetes or glycaemic traits outside pregnancy, which is the 'limited evidence' of the title; but 12 variants have stronger effects in gestational diabetes than in type 2 diabetes, four loci (G6PC2, CAST-PCSK1, HKDC1, FOXA2) have no genome-wide-significant type 2 diabetes association, GCK shows distinct causal variants, and MTNR1B's effect is amplified in pregnancy. Seven of the study's positions are on this site under other traits, including rs560887 (G6PC2), rs11558471 (SLC30A8), rs849134 (JAZF1) and rs4665972 (GCKR). It sits beside this site's gestational diabetes page, which is built on a separate 2026 study. PMID:42225636.

Questions about rs849134

What is rs849134?

rs849134 is a single position in the genome, in or near the JAZF1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs849134 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs849134?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs849134 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs849134 come from?

GWAS Catalog, Nat Genet 2010, PMID:20581827. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs849134). MyGeneLog™. https://www.mygenelog.com/variants/rs849134

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