C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Response to metformin in type 2 diabetes (HbA1c reduction) compared to the general population. (GWAS Catalog, Nat Genet 2016, PMID:27500523)
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Response to metformin in type 2 diabetes (HbA1c reduction). (GWAS Catalog, Nat Genet 2016, PMID:27500523)
T/TPublished research associates this genotype with typical/baseline likelihood of Response to metformin in type 2 diabetes (HbA1c reduction) — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2016, PMID:27500523)
rs8192675 is a single position in the genome, in or near the SLC2A2 gene. Published research associates it with response to metformin in type 2 diabetes (hba1c reduction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs8192675 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does rs8192675 affect how medicines work?
SLC2A2 carries pharmacogenomic findings for Metformin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs8192675 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs8192675 come from?
GWAS Catalog, Nat Genet 2016, PMID:27500523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.