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Serum levels of protein FAM189A2

NELL1 · rs8176786

Where this position leads

Drug: Hydrochlorothiazide

rs8176786 Drug: Hydrochlorothiazide Hydrochlorothiazide Drug rs8176786 rs8176786 NELL1

What the study found

Who was studied 5,367 Icelandic ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.928 higher (95% confidence interval 0.85-1); p = 4 × 10−122.

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 11, band 11p15.1 — a missense change in NELL1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Serum levels of protein FAM189A2 — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum levels of protein FAM189A2.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum levels of protein FAM189A2 compared to the general population.
Source
A genome-wide association study of serum proteins reveals shared loci with common diseases
Gudjonsson A, Gudmundsdottir V, Axelsson GT, Gudmundsson EF, Jonsson BG, Launer LJ, Lamb JR, Jennings LL, Aspelund T, Emilsson V, Gudnason V
Nature communications · 2022 · PMID 35078996 · open access

Questions about rs8176786

What is rs8176786?

rs8176786 is a single position in the genome, in or near the NELL1 gene. Published research associates it with serum levels of protein fam189a2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs8176786 affect how medicines work?

NELL1 carries pharmacogenomic findings for Hydrochlorothiazide. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs8176786 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8176786 come from?

GWAS Catalog, Nature communications 2022, PMID:35078996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum levels of protein FAM189A2 (rs8176786). MyGeneLog™. https://www.mygenelog.com/variants/rs8176786

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