One of the most widely prescribed blood pressure drugs, and one already known to raise blood sugar and triglycerides in some people. A common variant moves how much.
Hydrochlorothiazide is one of the most widely prescribed antihypertensives, and it is already known to raise blood sugar and triglycerides in some people — the mechanism was not well understood. A genome-wide study across two clinical trials found a variant near NELL1 where each copy of the reported allele corresponded to about a 28 mg/dL rise in triglycerides after starting the drug, genome-wide significant in African American participants. NELL1 represses fat-cell differentiation in other contexts, which the authors suggest as a plausible route to the metabolic effect, though this study establishes the statistical association rather than the mechanism.
Duarte JD et al., The Pharmacogenomics Journal 2014 — genome-wide association analysis of adverse metabolic response to hydrochlorothiazide in African Americans. PMID:23400010
Every guideline above was written by people. Named here because they are contributors to this page in the same sense anybody else on this site is.
These are the positions in your own file that carry the genes above. Not every gene in a guideline is one we report — where that is the case the gene appears above without a variant here, and the note says so.
NELL1 · rs61652119
Read more →NELL1 · rs8176786
Read more →Hydrochlorothiazide is one of the most widely prescribed blood pressure drugs. It’s already known to raise blood sugar and triglycerides in some people, and a common variant moves how much.
Yes, on average. In a genome-wide study across two clinical trials, each copy of the reported NELL1-region allele corresponded to about a 28 mg/dL rise in triglycerides after starting hydrochlorothiazide, reaching genome-wide significance in African American participants.
No. Blood sugar and triglycerides are already routinely monitored in people taking hydrochlorothiazide regardless of genotype; this finding explains part of why the size of that known effect varies between people.
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Hydrochlorothiazide. MyGeneLog™. https://www.mygenelog.com/drugs/hydrochlorothiazide