ABO · rs8176741
Where this position leads
Condition: Glaucoma
What the study found
Who was studied 115,486 European ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.188 lower (95% confidence interval 0.13-0.25); p = 2 × 10−10.
How common The G allele had a frequency of about 94% in the people studied.
Where it sits Chromosome 9, band 9q34.2 — a synonymous change in ABO.
What ClinVar records
Classification
no classification for the single variant; no classification for the single variant (0 of 4 stars).
ClinVar record 1696778 NM_020469.4(ABO):c.657C>T (p.His219=)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs8176741 is a single position in the genome, in or near the ABO gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2018, PMID:29617998. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Intraocular pressure (rs8176741). MyGeneLog™. https://www.mygenelog.com/variants/rs8176741