Gene Knowledge Graph
UTC
Standard

Nephritis and nephropathy with pathological lesion (PheCode 580.32)

SLC7A9 · rs79180036

Where this position leads

Condition: Nephritis and Nephropathy with Pathological Lesion

rs79180036 Condition: Nephritis and Nephropathy with Pathological Lesion Nephritis and Nephropathy with Path… Condition rs79180036 rs79180036 SLC7A9

What the study found

Who was studied 677 African American or Afro-Caribbean cases, 120,312 African American or Afro-Caribbean controls, 1,690 European ancestry cases, 447,649 European ancestry controls, 256 Hispanic or Latin American cases, 59,386 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 3.93 lower (95% confidence interval 3.92-3.94); p = 2 × 10−11.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 19, band 19q13.11 — in an intron of SLC7A9.

What each result means

A/A No copy of the version the research linked to Nephritis and nephropathy with pathological lesion (PheCode 580.32). This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Nephritis and nephropathy with pathological lesion (PheCode 580.32). That is a smaller link than two copies.
C/C Two copies of the version the research linked to Nephritis and nephropathy with pathological lesion (PheCode 580.32). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs79180036

What is rs79180036?

rs79180036 is a single position in the genome, in or near the SLC7A9 gene. Published research associates it with nephritis and nephropathy with pathological lesion (phecode 580.32). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs79180036 linked to?

On MyGeneLog this position is linked to Nephritis and Nephropathy with Pathological Lesion. The research behind each link, and its sources, are set out on that condition page.

Does having rs79180036 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs79180036 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Nephritis and nephropathy with pathological lesion (PheCode 580.32) (rs79180036). MyGeneLog™. https://www.mygenelog.com/variants/rs79180036

← See all variants