Nephritis and Nephropathy with Pathological Lesion, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 2,623 cases and 627,347 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 6 positions for Nephritis and Nephropathy with Pathological Lesion, which the catalogue files as "Nephritis and nephropathy with pathological lesion (PheCode 580.32)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 2,623 cases and 627,347 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 6 positions: rs186102603 (CCDC146), rs144836537 (AUNIP), rs529129721 (CCDC88A), rs544351756 (near RNU6-259P), rs191639407 (near KC6), rs79180036 (SLC7A9). PMID:39024449.
The catalogue maps the 6 positions to 6 genes: CCDC146, AUNIP, CCDC88A, RNU6-259P, KC6, SLC7A9. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs186102603 in CCDC146 carries the strongest signal: P = 4 × 10-13, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Nephritis and Nephropathy with Pathological Lesion and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nephritis and Nephropathy with Pathological Lesion is diagnosed by a clinician — not from a genotype. None of the 6 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Nephritis and Nephropathy with Pathological Lesion comes down to these specific, well-studied positions — not a diagnosis.
CCDC146 · rs186102603
See detailed info →AUNIP · rs144836537
See detailed info →CCDC88A · rs529129721
See detailed info →near RNU6-259P · rs544351756
See detailed info →near KC6 · rs191639407
See detailed info →SLC7A9 · rs79180036
See detailed info →Databases, guidelines and references
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Nephritis and Nephropathy with Pathological Lesion. MyGeneLog™. https://www.mygenelog.com/conditions/nephritis-and-nephropathy-with-pathological-lesion
Nephritis and Nephropathy with Pathological Lesion is the condition the GWAS Catalog files under "Nephritis and nephropathy with pathological lesion (PheCode 580.32)". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 1 study, with each study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 2,623 cases and 627,347 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 6 genes: CCDC146, AUNIP, CCDC88A, RNU6-259P, KC6, SLC7A9. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Nephritis and Nephropathy with Pathological Lesion from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.