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Who was studied 254,641 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0322 lower (95% confidence interval 0.022-0.042); p = 2 × 10−10.
How common The G allele had a frequency of about 93% in the people studied.
Where it sits Chromosome 3, band 3q26.33 — between genes, 16.9 kb from RN7SL229P.
What each result means
A/ANo copy of the version the research linked to Fluid intelligence score (baseline). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Fluid intelligence score (baseline). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Fluid intelligence score (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40374629 · open access
Questions about rs78458734
What is rs78458734?
rs78458734 is a single position in the genome, in or near the near RN7SL229P gene. Published research associates it with fluid intelligence score (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs78458734 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs78458734 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs78458734 come from?
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 11Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others1Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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