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Cholesteryl Esters to Total Lipids in Small LDL percentage

near LPL · rs78300069

Where this position leads

Condition: Age-Related Macular Degeneration

rs78300069 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs78300069 rs78300069 near LPL

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0736 lower (95% confidence interval 0.061-0.086); p = 2 × 10−31.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 8, band 8p21.3 — between genes, 51.7 kb from LPL.

What each result means

C/C No copy of the version the research linked to Cholesteryl Esters to Total Lipids in Small LDL percentage. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cholesteryl Esters to Total Lipids in Small LDL percentage. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cholesteryl Esters to Total Lipids in Small LDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs78300069

What is rs78300069?

rs78300069 is a single position in the genome, in or near the near LPL gene. Published research associates it with cholesteryl esters to total lipids in small ldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78300069 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs78300069 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78300069 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesteryl Esters to Total Lipids in Small LDL percentage (rs78300069). MyGeneLog™. https://www.mygenelog.com/variants/rs78300069

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