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Who was studied 269,867 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 6.36 z-score lower; p = 2 × 10−10.
Where it sits Chromosome 5, band 5q31.3 — in an intron of NDUFA2.
What each result means
A/ATwo copies of the version the research linked to Intelligence. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Intelligence. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Intelligence. This is the starting point the study compared everyone against.
rs778591 is a single position in the genome, in or near the NDUFA2 gene. Published research associates it with intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs778591 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs778591 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs778591 come from?
GWAS Catalog, Nature genetics 2018, PMID:29942086. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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