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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 24,646 African American cases, 31,446 African American controls.
The effect
Each copy of the C allele shifted the measure 0.086 lower (95% confidence interval 0.057-0.115); p = 5 × 10−9.
How common The C allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 7, band 7p12.1 — between genes, 26 kb from GRB10.
What each result means
C/CTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
Nature genetics · 2020 · PMID 32541925 · open access
Questions about rs7781440
What is rs7781440?
rs7781440 is a single position in the genome, in or near the near GRB10 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7781440 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs7781440 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7781440 come from?
GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Type 2 diabetes (rs7781440). MyGeneLog™. https://www.mygenelog.com/variants/rs7781440