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Who was studied 80,724 European ancestry cases, 748,975 European ancestry controls.
The effect
Each copy of the T allele carried 0.92 times the odds of Lumbar disc herniation (95% confidence interval 0.9-0.95); p = 1 × 10−10.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 11, band 11q23.1 — between genes, 3.8 kb from POU2AF1.
What each result means
C/CNo copy of the version the research linked to Lumbar disc herniation. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Lumbar disc herniation. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Lumbar disc herniation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39511132 · open access
Questions about rs77651758
What is rs77651758?
rs77651758 is a single position in the genome, in or near the near POU2AF1 gene. Published research associates it with lumbar disc herniation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77651758 linked to?
On MyGeneLog this position is linked to Lumbar Disc Herniation. The research behind each link, and its sources, are set out on that condition page.
Does having rs77651758 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77651758 come from?
GWAS Catalog, Nature communications 2024, PMID:39511132. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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