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Who was studied 228 African American or Afro-Caribbean cases, 121,622 African American or Afro-Caribbean controls, 3,087 European ancestry cases, 447,533 European ancestry controls, 408 Hispanic or Latin American cases, 59,421 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 2.72 lower (95% confidence interval 2.68-2.75); p = 3 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 11, band 11q13.1 — in an intron of SCYL1.
What each result means
A/ANo copy of the version the research linked to Psoriatic arthropathy (PheCode 696.42). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Psoriatic arthropathy (PheCode 696.42). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Psoriatic arthropathy (PheCode 696.42). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs77569865
What is rs77569865?
rs77569865 is a single position in the genome, in or near the SCYL1 gene. Published research associates it with psoriatic arthropathy (phecode 696.42). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77569865 linked to?
On MyGeneLog this position is linked to Psoriatic Arthropathy. The research behind each link, and its sources, are set out on that condition page.
Does having rs77569865 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77569865 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 61212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot2Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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