Psoriatic Arthropathy, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 3,723 cases and 628,576 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Psoriatic Arthropathy — filed in the GWAS Catalog as "Psoriatic arthropathy (PheCode 696.42)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 7 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 3,723 cases and 628,576 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 7 positions on this page: rs372925782 (near KIAA0930), rs538519116 (GSTA5), rs577898960 (F10), rs567050291 (SLC22A23), rs550235695 (FLRT2-AS1), rs73971815 (IFIH1), rs77569865 (SCYL1). PMID:39024449.
The 7 positions lie in or near 7 genes: KIAA0930, GSTA5, F10, SLC22A23, FLRT2-AS1, IFIH1, SCYL1. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Verma A et al. 2024 reported the smallest P value on this page — P = 3 × 10-13 — at rs372925782 near KIAA0930.
Read this page as a list of findings about Psoriatic Arthropathy, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Psoriatic Arthropathy. The 7 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Psoriatic Arthropathy comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Psoriatic Arthropathy. MyGeneLog™. https://www.mygenelog.com/conditions/psoriatic-arthropathy
Psoriatic Arthropathy is the condition the GWAS Catalog files under "Psoriatic arthropathy (PheCode 696.42)". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 7 associated positions; the largest study behind this page recorded 3,723 cases and 628,576 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 7 genes: KIAA0930, GSTA5, F10, SLC22A23, FLRT2-AS1, IFIH1, SCYL1. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Psoriatic Arthropathy is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.