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Who was studied 1,458,999 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.25 higher; p = 4 × 10−10.
Where it sits Chromosome 3, band 3p12.1 — in an intron of CADM2.
What each result means
C/CNo copy of the version the research linked to Substance use disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Substance use disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Substance use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2026 · PMID 41057643 · open access
Questions about rs77566799
What is rs77566799?
rs77566799 is a single position in the genome, in or near the CADM2 gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs77566799 linked to?
On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs77566799 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77566799 come from?
GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Substance use disorder (rs77566799). MyGeneLog™. https://www.mygenelog.com/variants/rs77566799