Sensitive

Lung cancer

DQ141194 · rs7741164

Where this position leads

What the study found

Who was studied 6,877 East Asian ancestry never smoker cases, 6,277 East Asian ancestry never smoker controls; replicated in 5,878 East Asian ancestry never smoker cases, 7,046 East Asian ancestry never smoker controls.

The effect Each copy of the A allele carried 1.17 times the odds of Lung cancer (95% confidence interval 1.12-1.22); p = 6 × 10⁻¹³.

How common The A allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 6, band 6p21.1 — in an intron of FOXP4-AS1.

What each result means

A/A Two copies of the version the research linked to Lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Lung cancer. That is a smaller link than two copies.

G/G No copy of the version the research linked to Lung cancer. This is the starting point the study compared everyone against.

Source

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Wang Z, Seow WJ, Shiraishi K, Hsiung CA, Matsuo K, Liu J, Chen K, Yamji T, Yang Y, Chang IS, Wu C, Hong YC

and 138 more — show all

Burdett L, Wyatt K, Chung CC, Li SA, Yeager M, Hutchinson A, Hu W, Caporaso N, Landi MT, Chatterjee N, Song M, Fraumeni JF Jr, Kohno T, Yokota J, Kunitoh H, Ashikawa K, Momozawa Y, Daigo Y, Mitsudomi T, Yatabe Y, Hida T, Hu Z, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Yin Z, Li X, Ren Y, Guan P, Chang J, Tan W, Chen CJ, Chang GC, Tsai YH, Su WC, Chen KY, Huang MS, Chen YM, Zheng H, Li H, Cui P, Guo H, Xu P, Liu L, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Park JY, Kim YH, Sung JS, Park KH, Kim YT, Jung YJ, Kang CH, Park IK, Kim HN, Jeon HS, Choi JE, Choi YY, Kim JH, Oh IJ, Kim YC, Sung SW, Kim JS, Yoon HI, Kweon SS, Shin MH, Seow A, Chen Y, Lim WY, Liu J, Wong MP, Lee VH, Bassig BA, Tucker M, Berndt SI, Chow WH, Ji BT, Wang J, Xu J, Sihoe AD, Ho JC, Chan JK, Wang JC, Lu D, Zhao X, Zhao Z, Wu J, Chen H, Jin L, Wei F, Wu G, An SJ, Zhang XC, Su J, Wu YL, Gao YT, Xiang YB, He X, Li J, Zheng W, Shu XO, Cai Q, Klein R, Pao W, Lawrence C, Hosgood HD 3rd, Hsiao CF, Chien LH, Chen YH, Chen CH, Wang WC, Chen CY, Wang CL, Yu CJ, Chen HL, Su YC, Tsai FY, Chen YS, Li YJ, Yang TY, Lin CC, Yang PC, Wu T, Lin D, Zhou B, Yu J, Shen H, Kubo M, Chanock SJ, Rothman N, Lan Q

Human molecular genetics · 2016 · PMID 26732429

Questions about rs7741164

What is rs7741164?

rs7741164 is a single position in the genome, in or near the DQ141194 gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7741164 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs7741164 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7741164 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:26732429. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung cancer (rs7741164). MyGeneLog™. https://www.mygenelog.com/variants/rs7741164

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