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Who was studied 2,466 Black/admixed ancestry individuals; replicated in up to 1,653 European, Hispanic, Asian or Black individuals.
The effect
Each copy of the T allele shifted the measure 0.659 higher (95% confidence interval 0.49-0.83); p = 9 × 10−14.
Where it sits Chromosome 12, band 12p12.1 — inside SLCO1B1.
What ClinVar records
ClassificationConflicting classifications of pathogenicity for Rotor syndrome, SLCO1B1-related disorder, Hepatocellular carcinoma; criteria provided, conflicting classifications (1 of 4 stars, 4 submitters), last evaluated 2026-09-10.
ClinVar record 307938NM_006446.5(SLCO1B1):c.481+1G>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
G/GNo copy of the version the research linked to Metabolite peak levels (QI9963). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Metabolite peak levels (QI9963). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Metabolite peak levels (QI9963). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 35995766 · open access
Questions about rs77271279
What is rs77271279?
rs77271279 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with metabolite peak levels (qi9963). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs77271279 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs77271279 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs77271279 come from?
GWAS Catalog, Nature communications 2022, PMID:35995766. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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