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Congenital factor V deficiency

F5 · rs770011773

Where this position leads

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Congenital factor V deficiency, Glioma susceptibility 1; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2022-11-29. ClinVar record 1452773 NM_000130.5(F5):c.1600C>T (p.Arg534Ter)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Congenital factor V deficiency. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV001452773, criteria provided, multiple submitters, no conflicts)

A/G One copy of the version ClinVar lists as disease-causing for Congenital factor V deficiency. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV001452773, criteria provided, multiple submitters, no conflicts)

G/G No copy of the version ClinVar lists as disease-causing for Congenital factor V deficiency. This is the usual result. (ClinVar VCV001452773, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV001452773, criteria provided, multiple submitters, no conflicts

Questions about rs770011773

What is rs770011773?

rs770011773 is a single position in the genome, in or near the F5 gene. Published research associates it with congenital factor v deficiency. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs770011773 affect how medicines work?

F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs770011773 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs770011773 come from?

ClinVar VCV001452773, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Congenital factor V deficiency (rs770011773). MyGeneLog™. https://www.mygenelog.com/variants/rs770011773

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