Who was studied 118,811 European ancestry cases, 327,427 European ancestry controls, 127,552 cases, 233,763 controls; replicated in 414,055 European ancestry cases, 892,299 European ancestry controls.
The effect
Each copy of the A allele carried 1.02 times the odds of Depression (95% confidence interval 1.013-1.022); p = 6 × 10−15.
How common The A allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 4, band 4p16.3 — in an intron of HTT.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
G/GPublished research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
rs7685686 is a single position in the genome, in or near the HTT gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7685686 linked to?
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
Does having rs7685686 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7685686 come from?
GWAS Catalog, Nat Neurosci 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.