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Forced vital capacity change in idiopathic pulmonary fibrosis

near SLC35B3 · rs76782037

Where this position leads

Condition: Idiopathic Pulmonary Fibrosis

rs76782037 Condition: Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Condition rs76782037 rs76782037 near SLC35B3

What the study found

Who was studied 1,048 European ancestry individuals; replicated in 281 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 265 lower (95% confidence interval -360.0--170.0); p = 4 × 10−8.

How common The C allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 6, band 6p24.3 — between genes, 71.7 kb from SLC35B3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Forced vital capacity change in idiopathic pulmonary fibrosis compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Forced vital capacity change in idiopathic pulmonary fibrosis.
T/T Published research associates this genotype with typical/baseline likelihood of Forced vital capacity change in idiopathic pulmonary fibrosis — no copies of the reported risk allele.
Source
Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study
Allen RJ, Oldham JM, Jenkins DA, Leavy OC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS, Fahy WA, Oballa E, Hubbard RB
and 19 more — show all
Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flores C, Noth I, Gisli Jenkins R, Wain LV
CleanUP-IPF Investigators of the Pulmonary Trials Cooperative
The Lancet. Respiratory medicine · 2023 · PMID 35985358 · open access

Questions about rs76782037

What is rs76782037?

rs76782037 is a single position in the genome, in or near the near SLC35B3 gene. Published research associates it with forced vital capacity change in idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76782037 linked to?

On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs76782037 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76782037 come from?

GWAS Catalog, The Lancet. Respiratory medicine 2023, PMID:35985358. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Forced vital capacity change in idiopathic pulmonary fibrosis (rs76782037). MyGeneLog™. https://www.mygenelog.com/variants/rs76782037

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