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Self-reported math ability

DPYD · rs76586805

Where this position leads

Condition: Educational Attainment

Drug: Fluoropyrimidines

rs76586805 Condition: Educational Attainment Educational Attainment Condition Drug: Fluoropyrimidines Fluoropyrimidines Drug rs76586805 rs76586805 DPYD

What the study found

Who was studied 564,698 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0245 higher (95% confidence interval 0.018-0.031); p = 6 × 10−13.

How common The T allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.

What each result means

C/C No copy of the version the research linked to Self-reported math ability. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Self-reported math ability. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Self-reported math ability. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T
and 65 more — show all
Lee C, Li H, Li R, Royer R, Timshel PN, Walters RK, Willoughby EA, Yengo L, Alver M, Bao Y, Clark DW, Day FR, Furlotte NA, Joshi PK, Kemper KE, Kleinman A, Langenberg C, Mägi R, Trampush JW, Verma SS, Wu Y, Lam M, Zhao JH, Zheng Z, Boardman JD, Campbell H, Freese J, Harris KM, Hayward C, Herd P, Kumari M, Lencz T, Luan J, Malhotra AK, Metspalu A, Milani L, Ong KK, Perry JRB, Porteous DJ, Ritchie MD, Smart MC, Smith BH, Tung JY, Wareham NJ, Wilson JF, Beauchamp JP, Conley DC, Esko T, Lehrer SF, Magnusson PKE, Oskarsson S, Pers TH, Robinson MR, Thom K, Watson C, Chabris CF, Meyer MN, Laibson DI, Yang J, Johannesson M, Koellinger PD, Turley P, Visscher PM, Benjamin DJ, Cesarini D
23andMe Research Team · COGENT (Cognitive Genomics Consortium) · Social Science Genetic Association Consortium
Nature genetics · 2018 · PMID 30038396

Questions about rs76586805

What is rs76586805?

rs76586805 is a single position in the genome, in or near the DPYD gene. Published research associates it with self-reported math ability. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76586805 linked to?

On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.

Does rs76586805 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs76586805 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76586805 come from?

GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Self-reported math ability (rs76586805). MyGeneLog™. https://www.mygenelog.com/variants/rs76586805

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