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Monocyte count

KLRC2 · rs76478238

Where this position leads

Conditions: Monocyte Count, Blood Cell Counts

rs76478238 Condition: Monocyte Count Monocyte Count Condition Condition: Blood Cell Counts Blood Cell Counts Condition rs76478238 rs76478238 KLRC2

What the study found

Who was studied 349,856 European ancestry individuals, 95,119 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0404 higher (95% confidence interval 0.034-0.047); p = 3 × 10−32.

Where it sits Chromosome 12, band 12p13.2 — in an intron of KLRC2.

What each result means

C/C Two copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/T No copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
Source

Questions about rs76478238

What is rs76478238?

rs76478238 is a single position in the genome, in or near the KLRC2 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76478238 linked to?

On MyGeneLog this position is linked to Monocyte Count, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs76478238 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76478238 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Monocyte count (rs76478238). MyGeneLog™. https://www.mygenelog.com/variants/rs76478238

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