Sensitive

Systemic sclerosis

FLG2 · rs76285340

Where this position leads

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Systemic sclerosis — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic sclerosis.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic sclerosis compared to the general population.

Source

Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population

Pu W, Wu W, Liu Q, Ma Y, Tu W, Zuo X, Guo G, Jiang S, Zhao Y, Zuo X, Wang Q, Yang L

and 32 more — show all

Xiao R, Chu H, Wang L, Sun L, Cui J, Yu L, Li H, Li Y, Shi Y, Zhang J, Zhang H, Liang M, Chen D, Ding Y, Chen X, Chen Y, Zhang R, Zhao H, Li Y, Qi Q, Bai P, Zhao L, Reveille JD, Mayes MD, Jin L, Lee EB, Zhang X, Xu J, Zhang Z, Zhou X, Zou H, Wang J

The Journal of investigative dermatology · 2021 · PMID 33069728

Questions about rs76285340

What is rs76285340?

rs76285340 is a single position in the genome, in or near the FLG2 gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76285340 linked to?

On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs76285340 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76285340 come from?

GWAS Catalog, J Invest Dermatol 2020, PMID:33069728. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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