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Who was studied 273 African American or Afro-Caribbean cases, 121,331 African American or Afro-Caribbean controls, 687 European ancestry cases, 449,900 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 2.09 lower (95% confidence interval 2.03-2.14); p = 3 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 6, band 6p21.1 — between genes, 22.1 kb from FOXP4-AS1.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acquired hemolytic anemias (PheCode 283) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acquired hemolytic anemias (PheCode 283).
T/TPublished research associates this genotype with typical/baseline likelihood of Acquired hemolytic anemias (PheCode 283) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs76198578
What is rs76198578?
rs76198578 is a single position in the genome, in or near the near FOXP4-AS1 gene. Published research associates it with acquired hemolytic anemias (phecode 283). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs76198578 linked to?
On MyGeneLog this position is linked to Acquired Hemolytic Anemias. The research behind each link, and its sources, are set out on that condition page.
Does having rs76198578 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76198578 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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