Acquired Hemolytic Anemias, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 960 cases and 571,231 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Acquired Hemolytic Anemias — filed in the GWAS Catalog as "Acquired hemolytic anemias (PheCode 283)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 7 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 960 cases and 571,231 controls (African American or Afro-Caribbean ancestry, European ancestry). The 7 positions on this page from it: rs540777345 (near Y_RNA), rs532423545 (near DMXL1-DT), rs139069715 (ZBTB43), rs192783417 (near EQTN), rs181512541 (CNTLN), rs555460019 (ADGRA2), rs576531990 (SBF2). PMID:39024449.
The 7 positions sit in or beside 7 genes: Y_RNA, DMXL1-DT, ZBTB43, EQTN, CNTLN, ADGRA2, SBF2. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 5 × 10-15 — at rs540777345 near Y_RNA.
Read this page as a list of findings about Acquired Hemolytic Anemias, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Acquired Hemolytic Anemias. The 7 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Acquired Hemolytic Anemias comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Acquired Hemolytic Anemias. MyGeneLog™. https://www.mygenelog.com/conditions/acquired-hemolytic-anemias
Acquired Hemolytic Anemias is the condition the GWAS Catalog files under "Acquired hemolytic anemias (PheCode 283)". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 1 study, with each study's sample and citation.
Genes play a part: 7 positions have been linked to it, the largest study recording 960 cases and 571,231 controls (African American or Afro-Caribbean ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 7 genes: Y_RNA, DMXL1-DT, ZBTB43, EQTN, CNTLN, ADGRA2, SBF2. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Acquired Hemolytic Anemias from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.