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Feeling miserable

RABGAP1L · rs75650221

Where this position leads

Condition: Irritable Mood

rs75650221 Condition: Irritable Mood Irritable Mood Condition rs75650221 rs75650221 RABGAP1L

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Feeling miserable — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling miserable.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling miserable compared to the general population.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs75650221

What is rs75650221?

rs75650221 is a single position in the genome, in or near the RABGAP1L gene. Published research associates it with feeling miserable. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75650221 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does having rs75650221 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75650221 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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