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Idiopathic pulmonary fibrosis

GPR157 · rs7549256

Where this position leads

Condition: Idiopathic Pulmonary Fibrosis

rs7549256 Condition: Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Condition rs7549256 rs7549256 GPR157

What the study found

Who was studied 169 African American or Afro-Caribbean, African ancestry cases, 8,368 African American or Afro-Caribbean, African ancestry controls, 1,210 East Asian ancestry cases, 254,409 East Asian ancestry controls, 9,411 European ancestry cases, 1,057,284 European ancestry controls, 319 Hispanic or Latin American cases, 14,452 Hispanic or Latin American controls, 51 South Asian ancestry cases, 21,897 South Asian ancestry controls.

The effect Each copy of the A allele carried 0.91 times the odds of Idiopathic pulmonary fibrosis (95% confidence interval 0.88-0.94); p = 3 × 10−9.

Where it sits Chromosome 1, band 1p36.22 — in an intron of GPR157.

What each result means

A/A Two copies of the version the research linked to Idiopathic pulmonary fibrosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Idiopathic pulmonary fibrosis. That is a smaller link than two copies.
C/C No copy of the version the research linked to Idiopathic pulmonary fibrosis. This is the starting point the study compared everyone against.
Source

Questions about rs7549256

What is rs7549256?

rs7549256 is a single position in the genome, in or near the GPR157 gene. Published research associates it with idiopathic pulmonary fibrosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7549256 linked to?

On MyGeneLog this position is linked to Idiopathic Pulmonary Fibrosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs7549256 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7549256 come from?

GWAS Catalog, Cell genomics 2022, PMID:36777997. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Idiopathic pulmonary fibrosis (rs7549256). MyGeneLog™. https://www.mygenelog.com/variants/rs7549256

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