Standard

Fluid intelligence

near MACIR · rs75457267

Where this position leads

Condition: Intelligence

rs75457267 Condition: Intelligence Intelligence Condition rs75457267 rs75457267 near MACIR

What the study found

Who was studied 182,798 British ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0472 higher; p = 1 × 10−10.

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 5, band 5q21.1 — between genes, 44.4 kb from MACIR.

What each result means

C/C No copy of the version the research linked to Fluid intelligence. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Fluid intelligence. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Fluid intelligence. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs75457267

What is rs75457267?

rs75457267 is a single position in the genome, in or near the near MACIR gene. Published research associates it with fluid intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs75457267 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs75457267 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75457267 come from?

GWAS Catalog, Communications biology 2026, PMID:42092107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Fluid intelligence (rs75457267). MyGeneLog™. https://www.mygenelog.com/variants/rs75457267

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